Homeobox genes d11–d13 and a13 control mouse autopod cortical bone and joint formation
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چکیده
منابع مشابه
Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation.
The molecular mechanisms that govern bone and joint formation are complex, involving an integrated network of signaling pathways and gene regulators. We investigated the role of Hox genes, which are known to specify individual segments of the skeleton, in the formation of autopod limb bones (i.e., the hands and feet) using the mouse mutant synpolydactyly homolog (spdh), which encodes a polyalan...
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Most homeobox [5] genes [4] contain a 180-base-pair region called a homeodomain [6]. The homeodomain [6] portion of the protein transcript has been shown to interact with DNA in a cisregulatory fashion during the critical stages of early body plan specification and embryogenesis [7]. These sorts of interactions demonstrate the importance of regulatory genes [4] and their architectural role in t...
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abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
Bone and joint diseases: prevention and control.
Arthritis is Australia’s major cause of disability and chronic pain. In Australian women, osteoarthritis is the third leading cause of years lost due to disability. Osteoporosis affects nearly two million Australians. The Federal government acknowledged the importance of musculoskeletal diseases by designating arthritis and musculoskeletal diseases as the seventh National Health Priority. This ...
متن کاملGradient fields and homeobox genes.
We review here old experiments that defined the existence of morphogenetic gradient fields in vertebrate embryos. The rather abstract idea of cell fields of organ-forming potential has become less popular among modern developmental and molecular biologists. Results obtained with antibodies directed against homeodomain proteins suggest that gradient fields may indeed be visualized at the level o...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2010
ISSN: 0021-9738
DOI: 10.1172/jci41554